Cell Selection as Driving Force in Lung and Colon Carcinogenesis

ention and Epidemiology l Selection as Driving Force in Lung and R on Carcinogenesis

Downlo cinogenesis is the result of mutations and subsequent clonal expansions of mutated, selectively advans cells. To investigate the relative contributions of mutation versus cell selection in tumorigenesis, we red two mathematical models of carcinogenesis in two different cancer types: lung and colon. One ach is based on a population genetics model, the Wright-Fisher process, whereas the ot...

Epidemiology l Selection as Driving Force in Lung and R on Carcinogenesis

nloaded cinogenesis is the result of mutations and subsequent clonal expansions of mutated, selectively advans cells. To investigate the relative contributions of mutation versus cell selection in tumorigenesis, we red two mathematical models of carcinogenesis in two different cancer types: lung and colon. One ach is based on a population genetics model, the Wright-Fisher process, whereas the o...

What Is The Driving Force Behind Industrial Development In Iran? Rent Seeking And Labor Exploitation As The Driving Force Of Industrial Growth

Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis

Oropharyngeal squamous cell carcinoma (OPSCC) has been known to be a highly aggressive disease associated with human papilloma virus (HPV) infection. To investigate the relationship between HPV and chronic inflammation in oropharyngeal carcinogenesis, we collected 140 oral mucous fresh specimens including 50 OPSCC patients, 50 cancer in situ, 30 precancerous lesions, and 10 normal oral mucous. ...

Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis

Sporadic colon cancer is caused predominantly by dietary factors. We have selected bile acids as a focus of this review since high levels of hydrophobic bile acids accompany a Western-style diet, and play a key role in colon carcinogenesis. We describe how bile acid-induced stresses cause cell death in susceptible cells, contribute to genomic instability in surviving cells, impose Darwinian sel...